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Previously, such full therapy effect overrides the effect of standard cytoprotective agents (which is only prophylactic and not therapy effect) (1-3), and results in its full implication in stomach cytoprotection and adaptive cytoprotection, as a representative of new class of cytoprotective agents (13, 30-33)

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The irritation requires stopping use, waiting for recovery, and restarting at appropriate levels, wasting both time and product