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5.6 Dietary regulation: tuning the gut microbiota-metabolite axis to enhance immunotherapy efficacy Dietary regulation shapes cancer immunotherapy outcomes by reprogramming the gut microbiota’s metabolic output—specifically, by enhancing production of immunostimulatory metabolites or reducing immunosuppressive ones—with efficacy rooted in the causal link between dietary components, microbial metabolism, and effector immune cell function

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People with compound heterozygous mutations, which means they carry one C677T and one A1298C mutation, can also experience issues with methylation