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Additionally, some studies investigate whether vitamin b12 on empty stomach supplementation has advantages, prompting questions like "Can you take vitamin b12 on an empty stomach to maximize absorption?" New research: Enhanced vitamin B12 absorption on an empty stomach A recent study, "Comparative Absorption of Vitamin B12 in Fasting and Fed States: Implications for Supplementation Practices," published in January 2025 in the Journal of Nutritional Science , examined the absorption rates of vitamin B12 when taken on an empty stomach versus with food