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Studies reveal that exposure to MPs (1 μm, 1 mg/kg, 5 mg/kg) and NPs (100 nm, 1 mg/L, 10 mg/L) reduces germinal epithelium stratification, disrupts spermatogenic cell alignment, and exacerbates interstitial fibrosis (80, 81)
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Patients at high risk of hepatotoxicity should have serial APAP level and hepatic function panels measured before the completion of NAC
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