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Compound 89 can be reacted with tert-butyl bromoacetate via a Suzuki cross-coupling reaction and, after ester hydrolysis, yields a carboxylic acid lenalidomide derivative (90) that can be attached to amine-containing linkers, leading to compound 91 147

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F2-IsoPs deserve special attention because serum F2-IsoPs levels were higher in asthma patients than in healthy subjects, and were also correlated with disease progression (85)