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Vitamin C is the same molecule whether you swallow an orange or run 50 grams through a vein, but the dose and the route change what it does in the body so completely that high-dose IV vitamin C is, pharmacologically, a different therapy than the supplement in your cabinet
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Because it plays such a key role in cellular defense against free radicals, SOD is also an important indicator of the oxidative state.(21) The glutathione precursor NAC is a small molecule containing a thiol group, which has antioxidant properties, and is freely filterable with ready access to intracellular compartments.(22) The diversity of pharmacological applications of NAC is due mainly to the chemical properties of the cysteinyl thiol group of its molecule, the ability of reduced thiol groups to scavenge oxygen free radicals having been well established.(23-25) In addition, NAC has a variety of anti-inflammatory effects.(26,27) In previous rat studies, the administration of NAC at doses of approximately 400 mg/kg has been shown to protect organs against oxidative damage.(28,29) In the present study, we found that NAC admin-istration after ischemia (prior to reperfusion) resulted in lower malondialdehyde levels, greater SOD activity, and higher glutathione levels in comparison with no treatment