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The lipophilicity and low molecular weight of DFP enable it to cross the cellular membranes and gain access into cardiomyocytes ( in vitro studies have shown that DFP can protect neonatal rat cardiomyocytes from cardiotoxicity induced by doxorubicin ( 4.3 Deferasirox DFX was the second oral chelator available for clinic use with high oral efficacy and tolerability

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Selon l’état du stress oxydatif cellulaire, on peut retrouver le Glutathion sous deux formes : à l’ état réduit, ou GSH , et à l’ état oxydé, ou GSSG