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First, because 4MP causes considerable phospho-JNK inhibition which negatively impacts p53 activation and necrosis 92 , we considered that 4MP causes a conservative 80% decrease of p53 activation and simulated this by multiplying the phosphorylation rate of p53 with parameter k 4MP JNK = 0.2 (i.e., decreasing the phosphorylation rate)
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