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Concerning this, an intriguing study has highlighted that in Caco-2/TC-7 enterocytes, propionic and butyric acids decreased the mRNA levels of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-Co-A), the rate-limiting enzyme of cholesterol production (233)
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In some experiments, 30 nM rapamycin (MCE, HY-10219) or 10 μM S3I-201 (MCE, HY-15146) were added along with amino acids