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In anti-apoptosis, it upregulates the Bcl-2/Bax ratio in dermal papilla cells and significantly downregulates apoptotic executors cleaved caspase-3 (by 42.7%) and PARP (by 77.5%), effectively protecting cells from apoptosis

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Hence, although a deficiency or lack of these markers by itself can never be taken as proof of cancer, it should not be dismissed if it comes hand-in-hand with other alarming signs

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