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In obesity, adipose tissue becomes enlarged and dysfunctional, leading to a chronic low-grade inflammation state and an increased secretion of pro-inflammatory cytokines such as TNF-alpha and IL-6, which also contribute to the development of metabolic disorders such as T2DM, hypertension, and cardiovascular disease [48,60,61]

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A: Interhaustral ring contraction (“segmentation”) leads to increased luminal pressure when there is simultaneous segment wall contraction