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Treatment with metformin was associated with longer overall survival at one (OR = 2.62, 95% CI: 1.76–3.90), three (OR = 3.14, 95%CI: 2.33–4.24), and five years (OR = 3.31, 95%CI: 2.39–4.59), and with significantly longer recurrence-free survival at one (OR = 2.52, 95%CI: 1.84–3.44) and three years (OR = 2.87, 95%CI: 2.15–3.84) but not at five years (OR = 2.26, 95%CI: 0.94–5.45) after curative treatment including hepatic resection and radiofrequency ablation therapy
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