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Three previously unknown reactions included the transsulfuration reaction to synthesize γ-Glu-Ser-Gly, the acetylation reaction to synthesize S-acetylglutathione, and the oxidation reaction to synthesize γ-Glu-3-sulfamoyl-Ala-Gly
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21 For example, lactate-induced H3K18la in CD4 + T cells and macrophages boosts CD39, CD73, and CCR8 gene expression, thereby leading to heightened regulatory T (Treg) cell infiltration in GBM and weakening chimeric antigen receptor (CAR)-T immunotherapy effectiveness
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