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The mass of peak 3 reacted in D 2 O (1328.6 Da, observed ion: m / z 665.3, z = 2), however, was 1 Da heavier than that reacted in H 2 O (1327.6 Da, observed ion: m / z 664.8, z = 2), indicating that the peptide incorporated a deuteron and, therefore, the presence of an isoAsp
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Additionally, some natural extracts can exert antioxidant and anti-inflammatory effects and regulate the Nrf2/HO-1/NQO1 and NF-κB/MAPK signaling pathways to treat AD (156, 157)