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The symptom or condition being treated Whether the diagnosis has been adequately evaluated Whether an FDA-approved treatment already exists Quality and relevance of human clinical evidence FDA status of the exact formulation and route Cancer history or abnormal growth-related findings Cardiovascular and blood-pressure history Pregnancy, fertility, or breastfeeding considerations Psychiatric and neurological history Medication and supplement interactions Baseline laboratory testing when clinically relevant Pharmacy sourcing, quality, and applicable law Monitoring plan and measurable treatment goals Criteria for stopping treatment An experimental therapy may occasionally be reasonable after informed discussion, but uncertainty must be part of the consent