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In a rat study, three groups of animals, when exposed to 0.8, 1.6 and 3.6 mg of PM2.5 once a week for 6 weeks, the ratio of ICP to mean atrial pressure (MAP) (i.e., ICP/MAP ratio) decreased, and the decline was higher in the high dose group

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Additionally, curcumin affects the Notch signaling pathway, leading to a decrease in CSC properties and promoting differentiation into non-tumorigenic cells [27]