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Although folic acid absorption by the intestine is catalyzed by the proton-coupled folate transporter (PCFT), which has similar affinity for both folic acid and reduced folates ( Table 2 ) (65, 66), the affinity for folic acid of the reduced folate carrier (RFC), which is ubiquitously expressed in all tissues, is 50- to 150-fold lower than that for 5-methylTHF and other reduced folates (Table 2) (65, 66)
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![PDF] Rethinking cystic fibrosis pathology: the critical role of abnormal reduced glutathione (GSH) transport caused by CFTR mutation](https://figures.semanticscholar.org/70a81b60f0aac18de75857cf65ee1823e7cb39bb/3-Figure1-1.png)
