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The paradoxical effects of EPA exemplify this complexity: while anti-inflammatory and antifibrotic under metabolically intact conditions, EPA may exacerbate hepatic lipid accumulation when mitochondrial β-oxidation is impaired
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The following section systematically describes the relationship between mitochondrial structure and targeting strategies across four distinct compartments—inner mitochondrial membrane (OMM), mitochondrial intermembrane space(IMS), the outer mitochondrial membrane (IMM), and mitochondrial matrix—integrated with recent research advances (see Table 1)
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