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Dysbiosis led to an increase in histamine and a decrease in taurine that, in turn, were related to alterations in the components of epithelial and subepithelial barrier components, the destruction of NLRP6, and a reduction in autophagia

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( E ) Semiquantitative scoring of demyelination (loss of LFB staining) in coronal paraffin sections of corpus callosum of vehicle- and XPro1595-treated CPZ0, CPZ3, and CPZ5 WT, Tnf –/– , or tm Tnf Δ/Δ mice ( n = 6–8 per group)