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ERV-LIKE PROTEIN FAMILY A family of flavoprotein thiol-oxidases — named after their homology to the yeast protein Erv1 — that couples the oxidation of free thiols with the reduction of molecular oxygen to hydrogen peroxide

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This reaction acts as a fundamental redox relay system, converting a short-lived, site-confined radical signal into a longer-lived, diffusible H 2 O 2 wave [16, 17, 72] (Fig