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Abbreviations The following abbreviations are used in this manuscript AML Acute myeloid leukemia ATP Adenosine triphosphate α-KG α-ketoglutarate BCAAs Branched-chain amino acids BCATs Branched-chain amino acid transferase BCKAs Branched-chain α-ketoacids BCKDH Branched-chain α-ketoacid dehydrogenase complex CAR-T Chimeric antigen receptor T-cell immunotherapy EB Eupalinolide B EGFR Epidermal growth factor receptor ER Estrogen receptor GSH Glutathione HCC Hepatocellular carcinoma HER2 Human epidermal growth factor receptor 2 HRR Homologous recombination repair IDH Isocitrate dehydrogenase IDO Indoleamine 2, 3-dioxygenase IFNγ Interferon gamma IL-15 Interleukin 15 LAT1 L-type amino acid transporter 1 MDSCs Myeloid-derived suppressor cells mTORC1 Mammalian target of rapamycin complex 1 NADPH Nicotinamide adenine dinucleotide phosphate NF-κB Nuclear factor kappa-B NK Natural killer NSCLC Non-small cell lung cancer PDAC Pancreatic ductal adenocarcinoma PD-1 Programmed cell death protein 1 PR Progesterone receptor RNF8 Ring finger protein 8 ROS Reactive oxygen species TAMs Tumor-associated macrophages TCA cycle Tricarboxylic acid cycle TKIs Tyrosine kinase inhibitors TME Tumor microenvironment TNBC Triple-negative breast cancer Contributor Information Chunhui Yang, Email: [email protected]

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Proc Natl Acad Sci USA 110:3507–3512