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Reduced lipogenesis and increased lipolysis in white adipose tissue Research demonstrated that NNMT inhibition by 5-Amino-1MQ reversed diet-induced obesity in mice, with significant reductions in body weight and white adipose tissue mass without affecting food intake

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Meaningful outcomes can include sleep-onset latency, total sleep time, nighttime awakenings, sleep efficiency, patient-reported sleep quality, daytime impairment, durability of benefit, and adverse effects