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“Not having enough folate during fetal development causes abnormalities of the brain,” says Dr Edward Quadros, a professor in the department of medicine at SUNY Downstate who specializes in folate absorption

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A study on rats showed that the ROS could activate the MAPK pathway to trigger autophagy in NP cells of rat and to modulate the generation of TNF- α , matrix metalloproteinase-3 (MMP-3), cyclooxygenase-2, and aggrecan expression in AF cells of rat [93, 94]