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Eine Clearance-Studie mit Enzymimmunoassay maß intravenöse Halbwertszeiten von etwa 4,0 Minuten beim Hund, 2,9 Minuten beim Affen und 2,0 Minuten bei der Ratte, mit einer metabolischen Clearance-Rate von rund 30,7 ml/kg/min beim Hund (PMID 6379493)