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43,49 The specific mechanism of SLC1 is described as binding endothelial cells via E-cadherin–selective endocytosis and then is transported into the endoplasmic reticulum, where the recombinant protein is cleaved into activated subunits, which are then released into the cytoplasm and provide a “blockade” to the assembly of the IKK complex to inhibit NF-κβ
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