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UBC9 upregulation of the SUMO E2 enzyme enhances protein quality control in the heart and promotes higher levels of autophagy, suggesting that increasing UBC9-mediated SUMO may be a novel strategy to treat heart disease, improve heart function, and increase survival (79)

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Pristane/hypoxia (PriHx) mouse as a novel model of pulmonary hypertension reflecting inflammation and fibrosis