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Downstream Cascade A — NAD+ Salvage and SIRT1 Activation NNMT normally acts as a “sink” for nicotinamide, permanently removing it from the NAD+ salvage pathway by methylating it into 1-MNA (which is then excreted)

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Dopamine reuptake inhibition: Increases dopamine in reward pathways Reduces food cravings and hedonic eating Enhances motivation and energy Similar to stimulant medications Creates euphoric feelings (can lead to dependency) 2