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[DOI] [Google Scholar] 16.Capozzi V, Russo P, Ladero V, Fernandez M, Fiocco D, Alvarez MA, Grieco F, Spano G

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while brain endothelial and nerve cells, red blood cells, lymphocytes - appear incapable of absorbing GSH as the intact tripeptide) L-methionine • Is an essential amino acid • It must first be converted to cysteine • This convertion is inactive in neonates and in certain adults, such as patients with liver disease • The "activated" methionine metabolite known as SAM (S-adenosyl methionine) is effective in raising red cell GSH and hepatic GSH when given orally at 1600 mg per day L-methionine • L-methionine intake is 13 mg per kg or about 0.75 gram daily for adults • During methionine supplementation, intake B6 and folic acid should also be included • Excessive methionine intake, together with inadequate intake of folic acid, vitamin B6, and vitamin B12, can increase the conversion of methionine to homocysteine • Homocysteine is a potentially harmful blood fat that has been linked to atherosclerosis Table 1