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314,315,316 An increase in peroxisome proliferator activated receptor gamma 2 (PPARγ2) and upregulation of hippocampal catalase in KD-fed rats are observed, which may increase anti-inflammatory and antioxidant activity

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Therapeutic strategy of IR Clinical approved treatment to IR No medications exist currently that are specifically approved to treat IR, but IR management 91,448,449 is possible through lifestyle changes like dietary, increased exercise, and disease prevention in addition to alternative medications (Fig

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