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Experimental investigations have examined the relationship between NNMT inhibition and regulatory pathways involving nicotinamide turnover, methylation dynamics, transcriptional control mechanisms, and downstream signal transduction processes
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PKA phosphorylation of PLIN1 releases ABHD5 to fully activate PNPLA2 (12, 16) and phosphorylation of HSL promotes HSL translocation from the cytosol to LDs (88, 89) to interact with PLIN1(15, 88, 90, 91) and increases its hydrolase activity for TAGs and DAGs (92) (Figure 2)
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