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Most patients begin experiencing metabolic improvements within the first several weeks, but meaningful blood pressure reductions usually develop gradually

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6.2.3.3 Cytokine dysregulation and myelin swelling Elevated levels of proinflammatory cytokines, such as TNF-α, and reduced levels of epidermal growth factor have been observed in Vit B12-deficient states (Scalabrino et al., 2000)