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During EAO CD4 + T cells, especially Th1 and Th17 populations, are activated and enriched in the testis, where they secrete IFN-γ, IL-1, IL-6 and other inflammatory cytokines that both directly injure the seminiferous epithelium and drive B cells to produce ASA, thus worsening tissue damage and dysfunction (153)

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Brief post-injection facial flushing The most consistent community feedback is a warmth and visible flush in the face, neck, and upper chest within 5-15 minutes of injection, fading by 30 minutes