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High intracellular reactive oxygen species (ROS) and Ca 2+ levels activate AMP-activated protein kinase (AMPK), which is necessary for the KA-induced apoptosis of hippocampal neurons [64]

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Russian clinical trials have contributed valuable data, but methodological differences, including smaller sample sizes, different statistical approaches, and less rigorous blinding procedures compared to FDA standards, mean that Western regulatory agencies generally do not accept this data for drug approval