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At concentrations of 0.1–10 μM, it dose-dependently inhibits cell proliferation, reduces the secretion of pro-inflammatory cytokines (TNF-α, IL-6, IL-8), inflammatory mediator (PGE 2 ), matrix metalloproteinases (MMP-1, MMP-13), and angiogenic factor VEGF, and downregulates the mRNA expression of COX-2, VEGF, HIF-1α, MMP-1, and MMP-13