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One study found that increased iron concentration present in the peritoneal fluid of women with endometriosis accelerated lipid peroxidation of spermatozoa, resulting in a detrimental action on the acrosome reaction, which plays an essential role during fertilization by making spermatozoa able to penetrate the zona and capable of fusing with the egg plasma membrane

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Alternatively, if there were no known agents which fulfilled the requirements of the standing concepts, the agent’s efficacy and activity would determine the opposition to the “law” of the standing concepts and form a new relevant concept