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In tumor-microenvironment models such as glioma co-culture, mitochondrial membrane potential, enzymatic activity, and ATP synthesis decline, while extracellular lactate production increases, indicating a metabolic shift from oxidative phosphorylation toward aerobic glycolysis (217)
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Animal models of inflammatory bowel disease show mucosal healing markers at 1 to 2 weeks with oral or intraperitoneal BPC-157
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