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Previous studies using genetic or small-molecule inhibitors of necroptosis via RIPK1/RIPK3/MLKL axis have given accumulating evidence regarding the essential role of necroptosis in ameliorating multi-organ inflammation such as skin inflammation (Bonnet et al., 2011), vascular inflammation (Lin et al., 2013), and inflammation of the pancreas (Wu et al., 2013), liver (Gautheron et al., 2014), and intestine (Welz et al., 2011