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*Clinical response=reduction in complete Mayo score of ≥3 points and ≥30% from baseline with an accompanying decrease in rectal bleeding subscore of ≥1 point or absolute rectal bleeding subscore of ≤1 point

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SAHA, the pan-HDAC inhibitor in clinical practice, has been found to restore mitochondrial integrity and function in ABCD1 silenced oligodendrocytes and astrocytes (124) and reduce the expression of proinflammatory cytokines, iNOS, as well as the activation of NF-κB in ABCD1/ABCD2-silenced mice primary astrocytes (125)