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The upregulation of p-AMPK, SIRT1, and PGC-1α has also been observed in LPS-stimulated Caco-2 cells after treatment with sulforaphane, which is also coupled with the upregulation of antioxidant enzymes (e.g., SOD, GPx, and CAT) and the downregulation of inflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-α) [135]
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