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This very prominent variant allele has been seen in about half of the East Asian populations studied (including the Han Chinese, Taiwanese, and Japanese) but has not been observed in populations of Caucasian ancestry (120, 172, 173)
immune function
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This contraindication stems from observations in rodent studies where semaglutide and other GLP-1 receptor agonists caused dose-dependent and treatment-duration-dependent thyroid C-cell tumors
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