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They discovered significantly higher levels of MTH1 and 8-oxodGTPase activity in tumor tissues across these cancer types, indicating that MTH1 could serve as a cancer biomarker ( 4.2 Regulation of signaling pathways by MTH1 In a separate study focusing on non-small cell lung cancer (NSCLC), it was discovered that MTH1 not only promotes the progression of NSCLC but also enhances activities in the MAPK pathway and PI3K/AKT in cancer cells

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The system x c – –GSH–GPX4 axis is regarded as the most classical and is the best-studied pathway in the regulation of ferroptosis