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Case reports and expert consensus instead highlight that tirzepatide alone achieves superior long-term weight loss (average 22 pounds at 21 weeks in STEP trials) without the tolerance decay that limits phentermine to 12 weeks of use

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▼ Measurable changes in fasting glucose and subjective energy typically appear within 7–10 days, while body composition shifts—reduced visceral adiposity and improved lean mass ratio—become evident at 4–6 weeks with consistent dosing