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Another study found the role of betaine in inhibiting the activation of NLR family pyrin domain-containing 3 (NLRP3) inflammasome

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Exposure of astroglia-rich primary cultures to IAA or IA in concentrations of up to 1 mM deprived the cells of GSH, inhibited cellular GAPDH activity, lowered cellular lactate production and caused a delayed cell death that was detectable after 90 min of incubation