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It's essential to ensure that the injection is administered by a trained professional to minimise the risk of complications and ensure the effectiveness of the treatment

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USP guidance describes the 28-day window as the period during which the bacteriostatic protection is engineered to suppress microbial proliferation from repeated puncture exposure — past that, the protection is no longer guaranteed, and the failure mode (cloudy reconstituted peptide, peptide aggregation) is documented but typically invisible until the peptide is reconstituted into the contaminated water