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Una Aparte de la característica común de una anemia (disminución de glóbulos rojos) la anemia por falta de B12 presenta un proceso de macrocitosis (aumento del tamaño de los glóbulos rojos o eritrocitos) que se manifiesta en el crecimiento anormal de las células sanguíneas (los ya comentados megaloblastos), fruto todo esto de una no maduración de su núcleo y de un incremento de la masa y de la maduración citoplasmática

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