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Petersburg Institute of Bioregulation and Gerontology developed it as a short, defined analog of Epithalamin, a bovine pineal-gland extract

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The association between MMP-9, p38 kinase and MCLK is likely mediated by the pro-inflammatory transcription factor NF-kB, as silencing of the p38 kinase prevented MMP-9 from activating NF-kB p65 and increasing MLCK expression [91]