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A similar result was also observed for the stroke volume

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In response to stimuli, such as membrane depolarisation by a neurotransmitter, cytosolic [Ca 2+ ] i is quickly increased within seconds (either released from intracellular Ca 2+ stores, such as the endoplasmic reticulum and the sarcolemma via ryanodine receptors (RyR), or via rapid intracellular influx through plasma membrane voltage-dependent Ca 2+ -channels) and may propagate further through Ca 2+ induced Ca 2+ release [22]