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In addition to the Hippo/Lats 15,23,24 and Piddosome 16 pathways acting through Tpr53 25 , our screen identified the Wnt signalling 19,26,27 , Proteasome-dependent degradation 28,29,30,31 , and autophagy pathways as mechanisms that signal arrest of cell proliferation in the presence of extra centrosomes
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