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Commonly Reported Side Effects Mild nausea or lightheadedness (typically early in the cycle) Redness or irritation at injection site Temporary headache or fatigue Tingling or “nerve sensitivity” in the treated area (rare) These effects are usually transient and dose-dependent

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Consistently, deletion of the H4K16 deacetylase Sir2 has been extensively reported to shorten replicative lifespan in yeast (Kaeberlein et al., 1999