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At the single-cell level, the lipid oxidation pathway in psoriatic keratinocytes is significantly upregulated compared to other cells such as fibroblasts, macrophages, dendritic cells, endothelial cells, and T cells, and it is highly associated with the Th22/Th17 pathway [206]

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Specifically, RBCs rendered dysfunctional through nutrient, temperature, or osmotic stress can nevertheless avoid lysis (which via the liberation of free heme, hemoglobin, and iron can be highly toxic) (Nemkov et al., 2020)